Coagulation
process in which the coagulation factors of the blood interact, ultimately resulting a clot
Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel forming a blood clot. The process involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. Coagulation results in hemostasis, the cessation of blood loss from a damaged vessel, allowing repair.
Coagulation begins almost instantly after an injury to the endothelium that lines a blood vessel. Exposure of blood to the subendothelial space initiates two processes: changes in platelets, and the exposure of subendothelial platelet tissue factor to coagulation factor VII, which ultimately leads to cross-linked fibrin formation. Platelets immediately form a plug at the site of injury; this is called primary hemostasis. Secondary hemostasis occurs simultaneously: additional coagulation factors beyond factor VII (listed below) respond in a cascade to form fibrin strands, which strengthen the platelet plug.
Coagulation is highly conserved throughout biology. In all mammals, coagulation involves both cellular components (platelets) and proteinaceous components (coagulation or clotting factors). The pathway in humans has been the most extensively researched and is the best understood.
The public source identifies “Coagulation” as process in which the coagulation factors of the blood interact, ultimately resulting a clot. This brief keeps that definition visible, then builds a research path around Coagulation, process and coagulation.
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The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Aug 19, 2026. The linked authority identifier is Q179217. The Library of Congress control number is sh85014936. 1 of 1 selected statements include explicit references; 1 carry qualifiers and 0 use preferred rank.
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This entry incorporates text from “Coagulation” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.