XLR-11
chemical compound
XLR-11 (5"-fluoro-UR-144 or 5F-UR-144) is a drug that acts as a potent agonist for the cannabinoid receptors CB1 and CB2 with EC50 values of 98 nM and 83 nM, respectively. It is a 3-(tetramethylcyclopropylmethanoyl)indole derivative related to compounds such as UR-144, A-796,260 and A-834,735, but it is not specifically listed in the patent or scientific literature alongside these other similar compounds, and appears to have not previously been made by Abbott Laboratories, despite falling within the claims of patent WO 2006/069196. XLR-11 was found to produce rapid, short-lived hypothermic effects in rats at doses of 3 mg/kg and 10 mg/kg, suggesting that it is of comparable potency to APICA and STS-135.
Detection
A forensic standard for this compound is available, and a representative mass spectrum has been posted on Forendex.
Recreational use
XLR-11 was instead first identified by laboratories in 2012 as an ingredient in synthetic cannabis smoking blends, and appears to be a novel compound invented specifically for grey-market recreational use.
Legal Status
XLR-11 was banned in New Zealand by being added to the temporary class drug schedule, as of 13 July 2012.
The U.S. Drug Enforcement Administration (DEA) made XLR11 illegal under the Federal Controlled Substances act for the foreseeable future as of January 2024.
It has also been banned in Florida as of 11 December 2012.
Arizona banned XLR-11 on 3 April 2013.
As of October 2015, XLR-11 is a controlled substance in China.
The public source identifies “XLR-11” as chemical compound. This brief keeps that definition visible, then builds a research path around XLR-11, chemical and compound.
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Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Apr 7, 2026. The linked authority identifier is Q8042267. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2006, 2012, 2024 and 2013.
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This entry incorporates text from “XLR-11” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.