MINDY2
protein-coding gene in the species Homo sapiens
Ubiquitin carboxyl-terminal hydrolase MINDY-2 is an enzyme which in humans is encoded by the gene MINDY2 (previously FAM63B). MINDY-2 functions to remove ubiquitin from proteins (specifically 'Lys-48'-linked conjugated ubiquitin), and may be involved in regulating the turnover of proteins in cells.
Gene
Locus
FAM63B is located at 15q21.3-q22.1, spanning 90,707 base pairs on chromosome 15.
Alternative Names
The full name of FAM63B is family with sequence similarity 63, member B. FAM63B is also listed by its alias, KIAA1164, in some publications.
mRNA
Isoforms
The FAM63B gene encodes a primary transcript that can be alternatively spliced into 9 protein variants. FAM63B variant a is the most common isoform found in humans.
Protein
Structure
Primary Structure
FAM63B is a member of the Pfam super family, and contains a domain of unknown function (DUF544) that is homologous within the protein family. FAM63B protein variant an also contains a bipartite tryptophan binding motif from W476 to W533. Variant a of the protein also contains a hydrophobic stretch of alanine from 567 to 574 and a mixed charge sequence from residue 598 to 617. FAM63B protein may contain a signal sequence specifying return to the endoplasmic reticulum (KDEL) from residue 607 to 621 in variant a.
“MINDY2” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what MINDY2, protein-coding and gene can confirm, complicate or overturn.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Aug 18, 2026. The linked authority identifier is Q18041142. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “MINDY2” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.