FAM204A
protein-coding gene in the species Homo sapiens
FAM204A (family with sequence similarity 204 member A) is a protein-coding gene that encodes the nuclear protein FAM204A in humans. The gene is located on chromosome 10 at position 10q26.11 and is ubiquitously expressed in human tissues.
Gene
FAM204A spans approximately 44 kilobases (kb) at chromosomal position 118.30 to 118.34 megabases (Mb) on the GRCh38 assembly and is transcribed from the minus (complementary) DNA strand. It contains eight exons and produces two validated mRNA isoforms (NM_022063.3 and NM_001134672.2) that encode the same 233‑amino acid protein. Other identifiers include C10orf84 and bA319I23.1.
FAM204A's upstream neighbor is RAB11FIP2, which encodes a protein predicted to mediate protein kinase binding and dimerization and is expressed ubiquitously, with localization in the nucleoplasm and endosomal compartments. Its downstream neighbor is the long non‐coding RNA CASC2 (cancer susceptibility candidate 2), implicated as a tumor suppressor and consistently observed to be downregulated in multiple cancer types.
Protein
The human FAM204A protein is 233 amino acids in length with a molecular weight of approximately 27 kilodaltons (kDa) and a predicted isoelectric point (pI) near 7.7.
FAM204A is lysine-rich and highly charged; nearly 40% of residues are basic or acidic. A lysine/arginine cluster between residues 95–114 resembles a nuclear localization signal (NLS) or nucleic acid-binding motif.
“FAM204A” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what FAM204A, protein-coding and gene can confirm, complicate or overturn.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Aug 5, 2025. The linked authority identifier is Q18045478. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “FAM204A” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.