Ergonovine
chemical compound

Ergonovine, also known as ergometrine and lysergic acid propanolamide, is a medication used to cause contractions of the uterus to treat heavy vaginal bleeding after childbirth. It can be used either by mouth, by injection into a muscle, or injection into a vein.
Common side effects include high blood pressure, vomiting, seizures, headache, and low blood pressure. Other serious side effects include ergotism.
Ergonovine was discovered in 1932. It is on the World Health Organization's List of Essential Medicines. Ergonovine is controlled in some countries because it can be used to make the psychedelic drug lysergic acid diethylamide (LSD). It is also known to produce psychedelic effects itself at high doses.
Medical uses
Ergonovine has a medical use in obstetrics to facilitate delivery of the placenta and to prevent bleeding after childbirth by causing smooth muscle tissue in the blood vessel walls to narrow, thereby reducing blood flow. It is usually combined with oxytocin (Syntocinon) as syntometrine.
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This entry incorporates text from “Ergonovine” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.