Ependyma
epithelial lining of the ventricular system of the brain and the central canal of the spinal cord, made up of ependymal cells

The ependyma is the thin neuroepithelial (simple columnar ciliated epithelium) lining of the ventricular system of the brain and the central canal of the spinal cord. The ependyma is one of the four types of neuroglia in the central nervous system (CNS). It is involved in the production of cerebrospinal fluid (CSF), and is shown to serve as a reservoir for neuroregeneration.
Structure
The ependyma is made up of ependymal cells called ependymocytes, a type of glial cell. These cells line the ventricles in the brain and the central canal of the spinal cord, which become filled with cerebrospinal fluid. These are nervous tissue cells with simple columnar shape, much like that of some mucosal epithelial cells. Early monociliated ependymal cells are differentiated to multiciliated ependymal cells for their function in circulating cerebrospinal fluid.
The basal membranes of these cells are characterized by tentacle-like extensions that attach to astrocytes. The apical side is covered in cilia and microvilli.
Function
Cerebrospinal fluid
Lining the CSF-filled ventricles, and spinal canal, the ependymal cells play an important role in the production and regulation of CSF. Their apical surfaces are covered in a layer of cilia, which circulate CSF around the CNS. Their apical surfaces are also covered with microvilli, which absorb CSF. Within the ventricles of the brain, a population of modified ependymal cells and capillaries together known as the tela choroidea form a structure called the choroid plexus, which produces the CSF.
Modified tight junctions between epithelial cells control fluid release.
Begin with the source’s own compact description: “Ependyma” is epithelial lining of the ventricular system of the brain and the central canal of the spinal cord, made up of ependymal cells. The dossier treats that line as a proposition to test through Ependyma, epithelial and lining, not as a finished interpretation.
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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Aug 31, 2026. The linked authority identifier is Q1134467. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Ependyma” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.