Electron resonance imaging
Method of visualizing living animals
Electron resonance imaging (ERI) is a preclinical imaging method, together with positron emission tomography (PET), computed tomography scan (CT scan), magnetic resonance imaging (MRI), and other techniques. ERI is dedicated to imaging small laboratory animals, and its unique feature is the ability to detect free radicals. This technique could also be used for other purposes, such as material science, quality of food, etc.
For in vivo imaging purposes, ERI is a minimally invasive method. It requires an intravenous injection of external substances called spin probes (usually nitroxide or triarylmethyl compounds). The main advantage of ERI modality is the ability to map the tissue microenvironment parameters, e.g., oxygen partial pressure (pO2), redox status, oxidative stress, thiol concentration, pH, inorganic phosphorus, viscosity, etc. ERI is commonly used to research in the areas of oncology, neurodegenerative disorders, and drug development.
Origin
ERI is a preclinical application of electron paramagnetic resonance imaging (EPRI). The term "ERI" was introduced to distinguish a commercial device from EPRI devices normally used in the academic domain.
Electron paramagnetic resonance (EPR) spectroscopy is dedicated to researching substances with unpaired electrons.
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