ERLIN1
protein-coding gene in the species Homo sapiens
Erlin-1 (Endoplasmic Reticulum lipid raft-associated 1) is a protein encoded by the ERLIN1 gene in humans.
ERLIN1 and its homolog ERLIN2 are ER-localized members of the stomatin/prohibition/flotillin/HflKC (SPFH) family of proteins. They form a complex that functions to scaffold lipids and proteins.
ERLIN1 and ERLIN2 are predicted to assemble in a large ring-shaped hetero-oligomeric complex, likely formed by 24 subunits, similar to other members of the SPFH family.
Function
ERLIN1/2 are associated with cholesterol homeostasis. They interact with the SCAP–SREBP2–INSIG complex tightly under cholesterol repletion conditions, thus keeping this complex in the ER, where it is inactive. Silencing of ERLINs releases SREBP2 from the ER and allows it to travel to the Golgi, where it is processed and drives transcription of cholesterol synthesis genes. Activation of the SREBP2 pathway is as potent under ERLINs silencing as it is under cholesterol depletion conditions.
The public source identifies “ERLIN1” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around ERLIN1, protein-coding and gene.
Why this record matters
A short description can identify a subject without explaining its stakes. For “ERLIN1”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 18, 2026. The linked authority identifier is Q18035529. None of the 0 selected statements returned an explicit reference.
Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
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Three-step research path
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Questions for further research
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This entry incorporates text from “ERLIN1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.