CACrown ArchivesThe cinema collection
EN/FR
Search
Menu
Research dossier · General Reference

Ectonucleotide pyrophosphatase/phosphodiesterase 1

mammalian protein found in Homo sapiens

Cross-disciplinary reference desk with index cards, atlas, dictionary and catalogue
General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionSep 6, 2026
Entity authorityQ21110158 ↗
Source-derived summary

Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (PC-1, CD203a) is an enzyme that in humans is encoded by the ENPP1 gene.

Structure

This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits.

Function

The main substrate of ENPP1 is adenosine triphosphate (ATP), which is cleaved into adenosine monophosphate (AMP) and diphosphate. Other notable substrates include cyclic guanosine monophosphate-adenosine monophosphate (cGAMP), nicotinamide adenine dinucleotide (NAD+) and cADPR.

ENPP3, a paralog of ENPP1, has also been identified as a major extracellular cGAMP hydrolase and is the second metazoan enzyme known to perform this function.

Clinical significance

Mutations in this gene have been associated with Generalized arterial calcification of infancy, ossification of the posterior longitudinal ligament of the spine (OPLL), Hypophosphatemic rickets autosomal recessive 2 (ARHR2), and insulin resistance.

In a tumor microenvironment, AMP generated by ENPP1 can lead to production of adenosine, which suppresses the anti-cancer function of the immune system.

Interactions

Ectonucleotide pyrophosphatase/phosphodiesterase 1 has been shown to interact with Insulin receptor.

Editorial summary

“Ectonucleotide pyrophosphatase/phosphodiesterase 1” enters the record as mammalian protein found in Homo sapiens. Crown Archives preserves that source wording while asking what Ectonucleotide, pyrophosphatase and phosphodiesterase can confirm, complicate or overturn.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current 174-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Ectonucleotide, pyrophosphatase and phosphodiesterase.
Editorial analysis

Why this record matters

“Ectonucleotide pyrophosphatase/phosphodiesterase 1” is worth following because a concise public description often conceals a longer documentary argument. Here, Ectonucleotide, pyrophosphatase and phosphodiesterase provides the most credible route into that argument.

Evidence profile

The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Sep 6, 2026. The linked authority identifier is Q21110158. None of the 0 selected statements returned an explicit reference.

Critical limits

A concise general-reference account can conceal disagreements about scope, terminology or the weight assigned to individual sources. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.

Best used for
  • Subject orientation
  • Search vocabulary
  • Locating named sources
Verify next

The closest primary source, responsible institution and strongest cited specialist reference.

Three-step research path

  1. Establish the record: confirm the title “Ectonucleotide pyrophosphatase/phosphodiesterase 1”, its source revision and the description used here.
  2. Expand the search: follow Ectonucleotide pyrophosphatase/phosphodiesterase 1 primary sources, Ectonucleotide pyrophosphatase/phosphodiesterase 1 archive and Ectonucleotide research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “Ectonucleotide pyrophosphatase/phosphodiesterase 1”?
  2. Which institution is responsible for the underlying evidence?
  3. What terminology or title could unlock a more precise catalogue search?
Subject index

Search terms from this dossier

Source & attribution

This entry incorporates text from “Ectonucleotide pyrophosphatase/phosphodiesterase 1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.