5-(carboxyamino)imidazole ribonucleotide synthase
class of enzymes
In enzymology, a 5-(carboxyamino)imidazole ribonucleotide synthase (EC 6.3.4.18) is an enzyme that catalyzes the chemical reaction
ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole + HCO3−
⇌
{\displaystyle \rightleftharpoons }
ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole
The 3 substrates of this enzyme are ATP, 5-amino-1-(5-phospho-D-ribosyl)imidazole ("AIR"), and HCO3−, whereas its 3 products are ADP, phosphate, and 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole.
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds. The systematic name of this enzyme class is 5-amino-1-(5-phospho-D-ribosyl)imidazole:carbon-dioxide ligase (ADP-forming).
References
Meyer E, Leonard NJ, Bhat B, Stubbe J, Smith JM (1992). "Purification and characterization of the purE, purK, and purC gene products: identification of a previously unrecognized energy requirement in the purine biosynthetic pathway". Biochemistry. 31 (21): 5022–32. doi:10.1021/bi00136a016. PMID 1534690.
Mueller EJ, Meyer E, Rudolph J, Davisson VJ, Stubbe J (1994).
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