N-acylglucosamine-6-phosphate 2-epimerase
class of enzymes
In enzymology, a N-acylglucosamine-6-phosphate 2-epimerase (EC 5.1.3.9) is an enzyme that catalyzes the chemical reaction
N-acyl-D-glucosamine 6-phosphate
⇌
{\displaystyle \rightleftharpoons }
N-acyl-D-mannosamine 6-phosphate
Hence, this enzyme has one substrate, N-acyl-D-glucosamine 6-phosphate, and one product, N-acyl-D-mannosamine 6-phosphate.
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is N-acyl-D-glucosamine-6-phosphate 2-epimerase. Other names in common use include acylglucosamine-6-phosphate 2-epimerase, and acylglucosamine phosphate 2-epimerase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB: 1Y0E and PDB: 1YXY.
References
Ghosh S, Roseman S (April 1965). "The Sialic Acids. Iv. N-Acyl--D-Glucosamine 6-Phosphate 2-Epimerase".
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