Enamidase
class of enzymes
In enzymology, an enamidase (EC 3.5.2.18) is an enzyme that catalyzes the chemical reaction
6-oxo-1,4,5,6-tetrahydronicotinate + 2 H2O
⇌
{\displaystyle \rightleftharpoons }
2-formylglutarate + NH3
Thus, the two substrates of this enzyme are 6-oxo-1,4,5,6-tetrahydronicotinate and H2O, whereas its two products are 2-formylglutarate and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 6-oxo-1,4,5,6-tetrahydronicotinate amidohydrolase.
References
Alhapel A, Darley DJ, Wagener N, Eckel E, Elsner N, Pierik AJ (2006). "Molecular and functional analysis of nicotinate catabolism in Eubacterium barkeri". Proc. Natl. Acad. Sci. U.S.A. 103 (33): 12341–6.
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