Maleimide hydrolase
class of enzymes
In enzymology, a maleimide hydrolase (EC 3.5.2.16) is an enzyme that catalyzes the chemical reaction
maleimide + H2O
⇌
{\displaystyle \rightleftharpoons }
maleamic acid
Thus, the two substrates of this enzyme are maleimide and H2O, whereas its product is maleamic acid.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is cyclic-imide amidohydrolase (decyclizing). Other names in common use include imidase, cyclic imide hydrolase, and cyclic-imide amidohydrolase (decyclicizing) [misprint].
References
Ogawa J, Soong CL, Honda M, Shimizu S (1997). "Imidase, a dihydropyrimidinase-like enzyme involved in the metabolism of cyclic imides". Eur. J. Biochem. 243 (1–2): 322–7. doi:10.1111/j.1432-1033.1997.0322a.x.
“Maleimide hydrolase” enters the record as class of enzymes. Crown Archives preserves that source wording while asking what Maleimide, hydrolase and class can confirm, complicate or overturn.
Why this record matters
“Maleimide hydrolase” is worth following because a concise public description often conceals a longer documentary argument. Here, Maleimide, hydrolase and class provides the most credible route into that argument.
The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Aug 26, 2023. The linked authority identifier is Q6742996. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1997, 1111, 1432 and 1033.
Overview language is designed for orientation and should not be treated as a substitute for the evidence cited beneath it. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “Maleimide hydrolase”, its source revision and the description used here.
- Expand the search: follow Maleimide hydrolase primary sources, Maleimide hydrolase archive and Maleimide research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “Maleimide hydrolase”?
- Which institution is responsible for the underlying evidence?
- What terminology or title could unlock a more precise catalogue search?
Search terms from this dossier
This entry incorporates text from “Maleimide hydrolase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.