Glycosylceramidase
class of enzymes
The enzyme glycosylceramidase (EC 3.2.1.62) catalyzes the following chemical reaction:
glycosyl-N-acylsphingosine + H2O
⇌
{\displaystyle \rightleftharpoons }
N-acylsphingosine + a sugar
It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycosyl-N-acylsphingosine glycohydrolase. Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, and phloridzin glucosidase.
References
Leese HJ, Semenza G (1973). "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase". J. Biol. Chem. 248 (23): 8170–3. doi:10.1016/S0021-9258(19)43209-2. PMID 4752949.
The public source identifies “Glycosylceramidase” as class of enzymes. This brief keeps that definition visible, then builds a research path around Glycosylceramidase, class and enzymes.
Why this record matters
A short description can identify a subject without explaining its stakes. For “Glycosylceramidase”, the useful work is to connect “class of enzymes” to the records capable of establishing context and consequence.
The citation trail is more important than the brevity of the summary: it shows where individual claims can be examined in context. The source revision retrieved here is dated Mar 1, 2025. The linked authority identifier is Q5572764. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1973 and 1016.
The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “Glycosylceramidase”, its source revision and the description used here.
- Expand the search: follow Glycosylceramidase primary sources, Glycosylceramidase archive and Glycosylceramidase research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “Glycosylceramidase”?
- What terminology or title could unlock a more precise catalogue search?
- Which institution is responsible for the underlying evidence?
Search terms from this dossier
This entry incorporates text from “Glycosylceramidase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.