Alanine—glyoxylate transaminase
class of enzymes
Alanine-glyoxylate transaminase (EC 2.6.1.44) is a pyridoxal phosphate-dependent enzyme that catalyzes the chemical reaction
The two substrates of this enzyme characterised from liver and kidney are L-alanine and glyoxylic acid. Its products are pyruvic acid and glycine.
This enzyme is a transferase, specifically a transaminase, which transfer nitrogenous groups. The systematic name of this enzyme class is L-alanine:glyoxylate aminotransferase. Other names in common use include AGT, alanine-glyoxylate aminotransferase, alanine-glyoxylic aminotransferase, and L-alanine-glycine transaminase.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes PDB: 1H0C, PDB: 1J04, PDB: 1VJO, PDB: 2BKW, PDB: 2HUF, PDB: 2HUI, and PDB: 2HUU.
The public source identifies “Alanine—glyoxylate transaminase” as class of enzymes. This brief keeps that definition visible, then builds a research path around Alanine, glyoxylate and transaminase.
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This entry incorporates text from “Alanine—glyoxylate transaminase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.