N-acylsphingosine galactosyltransferase
class of enzymes
In enzymology, a N-acylsphingosine galactosyltransferase (EC 2.4.1.47) is an enzyme that catalyzes the chemical reaction
UDP-galactose + N-acylsphingosine
⇌
{\displaystyle \rightleftharpoons }
UDP + D-galactosylceramide
Thus, the two substrates of this enzyme are UDP-galactose and N-acylsphingosine, whereas its two products are UDP and D-galactosylceramide.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:N-acylsphingosine D-galactosyltransferase. Other names in common use include UDP galactose-N-acylsphingosine galactosyltransferase, and uridine diphosphogalactose-acylsphingosine galactosyltransferase. This enzyme participates in sphingolipid metabolism.
References
Fujino Y, Nakano M (1969). "Enzymic synthesis of cerebroside from ceramide and uridine diphosphate galactose". Biochem. J. 113 (3): 573–5. doi:10.1042/bj1130573.
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