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Bis-gamma-glutamylcystine reductase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionFeb 23, 2026
Entity authorityQ3597035 ↗
Source-derived summary

Bis-gamma-glutamylcystine reductase (EC 1.8.1.13) is an enzyme that catalyzes the chemical reaction

The three substrates of this enzyme are bis-γ-glutamylcystine, reduced nicotinamide adenine dinucleotide phosphate (NADPH), and a proton. Its products are γ-L-Glutamyl-L-cysteine and oxidised NADP+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is gamma-glutamylcysteine:NADP+ oxidoreductase. This enzyme is also called NADPH2:bis-gamma-glutamylcysteine oxidoreductase. This enzyme participates in glutathione metabolism.

Editorial summary

This brief starts where responsible research should: with the source description of “Bis-gamma-glutamylcystine reductase” as class of enzymes. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current 82-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where Bis-gamma-glutamylcystine, reductase and class can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the general reference register because the source frames it as class of enzymes. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Feb 23, 2026. The linked authority identifier is Q3597035. None of the 0 selected statements returned an explicit reference.

Critical limits

The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.

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  2. Expand the search: follow Bis-gamma-glutamylcystine reductase primary sources, Bis-gamma-glutamylcystine reductase archive and Bis-gamma-glutamylcystine research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

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Source & attribution

This entry incorporates text from “Bis-gamma-glutamylcystine reductase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.