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1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 27, 2025
Entity authorityQ3133669 ↗
Source-derived summary

In enzymology, a 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase (EC 1.3.1.68) is an enzyme that catalyzes the chemical reaction

1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate + NAD+

⇌

{\displaystyle \rightleftharpoons }

3-methylcatechol + NADH + CO2

Thus, the two substrates of this enzyme are 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate and NAD+, whereas its 3 products are 3-methylcatechol, NADH, and CO2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating). This enzyme participates in toluene and xylene degradation.

References

Higson FK, Focht DD (1992). "Degradation of 2-methylbenzoic acid by Pseudomonas cepacia MB2". Appl. Environ. Microbiol. 58 (1): 194–200.

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“1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase” enters the record as class of enzymes. Crown Archives preserves that source wording while asking what 2-dihydroxy-6-methylcyclohexa-3, 5-dienecarboxylate and dehydrogenase can confirm, complicate or overturn.

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This entry incorporates text from “1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.