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2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionDec 22, 2025
Entity authorityQ2756657 ↗
Source-derived summary

2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase (EC 1.1.1.312, 2-hydroxy-4-carboxymuconate 6-semialdehyde dehydrogenase, 4-carboxy-2-hydroxy-cis,cis-muconate-6-semialdehyde:NADP+ oxidoreductase, alpha-hydroxy-gamma-carboxymuconic epsilon-semialdehyde dehydrogenase, 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase, LigC, ProD) is an enzyme with systematic name 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal:NADP+ 2-oxidoreductase. This enzyme catalyses the following chemical reaction:

Unsubstituted aliphatic or aromatic aldehydes or glucose cannot serve as substrate of this enzyme.

Editorial summary

Begin with the source’s own compact description: “2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase” is class of enzymes. The dossier treats that line as a proposition to test through 2-hydroxy-4-carboxymuconate, semialdehyde and hemiacetal, not as a finished interpretation.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current 49-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. For this dossier, 2-hydroxy-4-carboxymuconate, semialdehyde and hemiacetal is the immediate research focus.
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Why this record matters

The phrase “class of enzymes” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.

Evidence profile

Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Dec 22, 2025. The linked authority identifier is Q2756657. None of the 0 selected statements returned an explicit reference.

Critical limits

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This entry incorporates text from “2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.