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Amorpha-4,11-diene 12-monooxygenase

class of enzymes

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionApr 6, 2026
Entity authorityQ4027370 ↗
Source-derived summary

Amorpha-4,11-diene 12-monooxygenase (EC 1.14.14.114, CYP71AV1) is an enzyme with systematic name amorpha-4,11-diene,NADPH:oxygen oxidoreductase (12-hydroxylating). This enzyme catalyses the following overall chemical reaction

The reaction proceeds in three oxidations, each catalysed by the enzyme, which is a cytochrome P450 protein containing heme, isolated from Artemisia annua. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate. The product is used by the plant in the biosynthesis of artemisinin.

Editorial summary

This brief starts where responsible research should: with the source description of “Amorpha-4,11-diene 12-monooxygenase” as class of enzymes. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA dependable orientation record for establishing vocabulary, names and a first evidence trail. The current 73-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. The account is most persuasive where Amorpha-4, 11-diene and 12-monooxygenase can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the general reference register because the source frames it as class of enzymes. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Apr 6, 2026. The linked authority identifier is Q4027370. None of the 0 selected statements returned an explicit reference.

Critical limits

The absence of detail may reflect summary conventions rather than a lack of surviving documentation. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.

Best used for
  • Subject orientation
  • Search vocabulary
  • Locating named sources
Verify next

The closest primary source, responsible institution and strongest cited specialist reference.

Three-step research path

  1. Establish the record: confirm the title “Amorpha-4,11-diene 12-monooxygenase”, its source revision and the description used here.
  2. Expand the search: follow Amorpha-4,11-diene 12-monooxygenase primary sources, Amorpha-4,11-diene 12-monooxygenase archive and Amorpha-4 research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “Amorpha-4,11-diene 12-monooxygenase”?
  2. Which institution is responsible for the underlying evidence?
  3. Which cited source is closest to the event, object or claim?
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Source & attribution

This entry incorporates text from “Amorpha-4,11-diene 12-monooxygenase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.