Excitatory amino acid reuptake inhibitor
class of pharmaceutical compounds
An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake of the excitatory neurotransmitters glutamate and aspartate by blocking one or more of the excitatory amino acid transporters (EAATs).
Examples of EAARIs include dihydrokainic acid (DHK) and WAY-213,613, selective blockers of EAAT2 (GLT-1), and L-trans-2,4-PDC, a non-selective blocker of all five EAATs. Amphetamine is a selective noncompetitive reuptake inhibitor of presynaptic EAAT3 (via transporter endocytosis) in dopamine neurons. L-Theanine is reported to competitively inhibit reuptake at EAAT1 (GLAST) and EAAT2 (GLT-1).
“Excitatory amino acid reuptake inhibitor” enters the record as class of pharmaceutical compounds. Crown Archives preserves that source wording while asking what Excitatory, amino and acid can confirm, complicate or overturn.
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This entry incorporates text from “Excitatory amino acid reuptake inhibitor” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.