Drug-induced hyperthermia
symptom
Drug-induced fever is a symptom of an adverse drug reaction wherein the administration of drugs intended to help a patient causes a hypermetabolic state resulting in fever. The drug may interfere with heat dissipation peripherally, increase the rate of metabolism, evoke a cellular or humoral immune response, mimic endogenous pyrogen, or damage tissues.
Triggers
Directly caused by the drug, e.g. lamotrigine, progesterone, or chemotherapeutics causing tumor necrosis
Possible side effect of stimulants and entactogens (e.g. cocaine, MDMA, methamphetamine, PMA, 4-MTA)
As an adverse reaction to drugs, e.g. antibiotics or sulfa drugs.
After drug discontinuation, e.g. heroin or fentanyl withdrawal
Neuroleptic malignant syndrome; rare, life-threatening hyperpyrexia caused by antidopaminergic drugs (mostly antipsychotics) e.g. Haloperidol, Chlorpromazine
Serotonin syndrome; excessive serotonergic activity due usually to combined use of serotonergic drugs (e.g. antidepressants, stimulants, triptans)
5HT2A agonists, e.g.
“Drug-induced hyperthermia” enters the record as symptom. Crown Archives preserves that source wording while asking what Drug-induced, hyperthermia and symptom can confirm, complicate or overturn.
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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Jun 17, 2025. The linked authority identifier is Q718678. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Drug-induced hyperthermia” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.