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Dolichyl-phosphate alpha-N-acetylglucosaminyltransferase

class of enzymes

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionAug 3, 2025
Entity authorityQ5289107 ↗
Source-derived summary

In enzymology, a dolichyl-phosphate alpha-N-acetylglucosaminyltransferase (EC 2.4.1.153) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + dolichyl phosphate

⇌

{\displaystyle \rightleftharpoons }

UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate

Thus, the two substrates of this enzyme are UDP-N-acetyl-D-glucosamine and dolichyl phosphate, whereas its two products are UDP and dolichyl N-acetyl-alpha-D-glucosaminyl phosphate.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase. Other names in common use include uridine diphosphoacetylglucosamine-dolichol phosphate, acetylglucosaminyltransferase, dolichyl phosphate acetylglucosaminyltransferase, dolichyl phosphate N-acetylglucosaminyltransferase, UDP-N-acetylglucosamine-dolichol phosphate, and N-acetylglucosaminyltransferase.

References

Leloir LF, Staneloni RJ, Carminatti H, Behrens NH (1973). "The biosynthesis of a N,N'-diacetylchitobiose containing lipid by liver microsomes. A probable dolichol pyrophosphate derivative". Biochem. Biophys. Res.

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This entry incorporates text from “Dolichyl-phosphate alpha-N-acetylglucosaminyltransferase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.