Dalosirvat
chemical compound
Dalosirvat (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code name SM-04554) is a drug acting as a Wnt signaling pathway stimulant which is under development for the treatment of alopecia (hair loss). It is used topically as a solution. The drug is being developed by Biosplice Therapeutics (formerly known as Samumed). As of April 2021, it is in phase 2/3 clinical trials for this in Turkey. There have been no further updates on the development of dalosirvat as of October 2025. Two phase 2 trials have been completed and preliminary results released. In one of the trials, only a 0.15% concentration and not a higher 0.25% concentration showed effectiveness. A 625-patient phase 3 trial was reportedly started in 2018. It was reported in a 2023 literature review that dalosirvat had completed a phase 3 trial in early 2023 and that Biosplice Therapeutics had cancelled its development based on the trial's results.
The public source identifies “Dalosirvat” as chemical compound. This brief keeps that definition visible, then builds a research path around Dalosirvat, chemical and compound.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Jan 5, 2026. The linked authority identifier is Q105335037. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2021, 2025, 2018 and 2023.
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This entry incorporates text from “Dalosirvat” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.