Dacrocyte
cell type
A dacrocyte (or dacryocyte) is a type of poikilocyte that is shaped like a teardrop (a "teardrop cell"). A marked increase of dacrocytes is known as dacrocytosis.
These tear drop cells are found primarily in diseases with bone marrow fibrosis, such as: primary myelofibrosis, myelodysplastic syndromes during the late course of the disease, rare form of acute leukemias and myelophthisis caused by metastatic cancers. Rare causes are myelofibrosis associated with post-irradiation, toxins, autoimmune diseases, metabolic conditions, inborn hemolytic anemias, iron-deficiency anemia or β-thalassemia.
Etiology
One theory regarding dacrocyte formation is that red blood cells containing various inclusions undergo "pitting" by the spleen to remove these inclusions, and in the process, they can be stretched too far to return to their original shape. It is also thought that this can similarly occur when red blood cells with large inclusions are obstructed from passing through the microcirculation, and the portion containing the inclusion thus gets pinched, leaving a tailed end. As dacrocytes are associated with myelofibrosis, they are also theorized to be formed due to mechanically squeezing out from the bone marrow as a result of the infiltrative process.
“Dacrocyte” enters the record as cell type. Crown Archives preserves that source wording while asking what Dacrocyte, cell and type can confirm, complicate or overturn.
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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Nov 25, 2025. The linked authority identifier is Q3011654. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Dacrocyte” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.