DNA-deoxyinosine glycosylase
class of enzymes
DNA-deoxyinosine glycosylase (EC 3.2.2.15, DNA(hypoxanthine) glycohydrolase, deoxyribonucleic acid glycosylase, hypoxanthine-DNA glycosylase) is an enzyme with systematic name DNA-deoxyinosine deoxyribohydrolase. This enzyme is involved in DNA damage repair and targets hypoxanthine bases.
DNA is constantly exposed to chemical reactions within its cellular environment, leading to undesired structural changes and compromising the integrity of genetic information. Common changes to bases include oxidation, alkylation, or the deamination of bases. Observed deamination in DNA bases are cytosine to uracil, guanine to xanthine and oxanine, or adenine to hypoxanthine. These single-base legions are removed through the base excision repair (BER) pathway, a mechanism initiated by DNA glycosylase to remove a mismatch or mutated base.
DNA glycosylases are ubiquitous, observed in species of all kingdoms of life, including archaea, eubacteria, eukaryotes, and large DNA viruses. They can be further subdivided into four specific categories: the uracil DNA glycosylases (UDGs), the helix-hairpin-helix (HhH) glycosylases, the 3-methyl-purine glycosylase (MPG), and the endonuclease VIII-like (NEIL) glycosylases. However, DNA deoxyinosine glycosylase activity, the removal of a hypoxanthine base, is observed within the uracil DNA glycosylase superfamily. Currently, there are 6 families within the DNA Uracil Glycosylase superfamily, each classified based on their sequence homology, and biochemical and structural similarities.
Begin with the source’s own compact description: “DNA-deoxyinosine glycosylase” is class of enzymes. The dossier treats that line as a proposition to test through DNA-deoxyinosine, glycosylase and class, not as a finished interpretation.
Why this record matters
The phrase “class of enzymes” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.
Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Oct 1, 2025. The linked authority identifier is Q11216994. None of the 0 selected statements returned an explicit reference.
A concise general-reference account can conceal disagreements about scope, terminology or the weight assigned to individual sources. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “DNA-deoxyinosine glycosylase”, its source revision and the description used here.
- Expand the search: follow DNA-deoxyinosine glycosylase primary sources, DNA-deoxyinosine glycosylase archive and DNA-deoxyinosine research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “DNA-deoxyinosine glycosylase”?
- What terminology or title could unlock a more precise catalogue search?
- Which cited source is closest to the event, object or claim?
Search terms from this dossier
This entry incorporates text from “DNA-deoxyinosine glycosylase” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.