3,4-Dihydroxyphenylglycolaldehyde
chemical compound
3,4-Dihydroxyphenylglycolaldehyde (also known as DOPEGAL, 3,4-dihydroxymandelaldehyde, DHMAL, norepinephrine aldehyde, or epinephrine aldehyde) is a metabolite of the monoamine neurotransmitters norepinephrine and epinephrine. DOPEGAL is a noradrenergic neurotoxin.
Formation
DOPEGAL is formed by monoamine oxidase (MAO) via oxidative deamination. Following its formation, DOPEGAL is metabolized. Through the metabolism process, it is converted into 3,4-dihydroxymandelic acid (DHMA) via aldehyde dehydrogenase (ALDH), or into 3,4-dihydroxyphenylglycol (DHPG) via aldehyde reductase (ALR).
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated May 15, 2026. The linked authority identifier is Q27103374. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “3,4-Dihydroxyphenylglycolaldehyde” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.