Daf-12
protein found in Caenorhabditis elegans
The DAF-12 (abnormal dauer formation protein 12) gene encodes the nuclear receptor of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans, with the NRNC Symbol NR1J1 as the homolog of nuclear hormone receptor HR96 (Hr96) in Drosophila melanogaster. DAF-12 has been implicated by Cynthia Kenyon and colleagues in the formation of Dauer larva.
In favorable environments, a cytochrome p450 Daf-9 (Cyp22a1) produce dafachronic acid to binding Daf-12 to initiating downstream gene expression. When in unfavorable environments, like starvation, dafachronic acid decreases, Daf-12 will form a complex with co-repressor DIN-1.
“Daf-12” enters the record as protein found in Caenorhabditis elegans. Crown Archives preserves that source wording while asking what Daf-12, protein and found can confirm, complicate or overturn.
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Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Feb 9, 2026. The linked authority identifier is Q29796382. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Daf-12” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.