PBDC1
protein-coding gene in the species Homo sapiens
CXorf26 (Chromosome X Open Reading Frame 26), also known as MGC874, is a well conserved human gene found on the plus strand of the short arm of the X chromosome. The exact function of the gene is poorly understood, but the polysaccharide biosynthesis domain that spans a major portion of the protein product (known as UPF0368), as well as the yeast homolog, YPL225, offer insights into its possible function.
Gene
CXorf26 is found on the plus strand of the short arm of the X chromosome, specifically on the gene locus Xq13.3 spanning the genomic chromosome region from bases 75,393,420-75,397,740. The primary mRNA transcript sequence has 1214 base pairs and its protein product, UPF0368, is composed of 233 amino acids and has a predicted mass of 26,057 Da.
The locus where CXorf26 is located, Xq13.3, has known associations to X-linked mental retardation.
The third gene located upstream of CXorf26 is ATRX, which encodes for an ATPase/helicase domain, and when mutated causes an X-linked mental retardation syndrome along with alpha thalassemia syndrome; both are known to cause changes in the DNA methylation patterns. Furthermore, the third gene downstream of CXorf26, ZDHHC15, which when mutated, causes mental retardation X-linked type 91. One noteworthy gene located nearby is Xist, which plays a role in the inactivation process of the X chromosome. X inactivation relates to CXorf26, and is discussed below in the relevant research section.
Alternative splice forms
There is only one alternative splice form for CXorf26.
This brief starts where responsible research should: with the source description of “PBDC1” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.
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The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 24, 2026. The linked authority identifier is Q18040133. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1214.
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This entry incorporates text from “PBDC1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.