Cosegregation
the transmission, together, of 2 or more genes on the same chromosome, as a result of their being in very close physical proximity to one another (i.e., linked).
Cosegregation, in genealogy, refers to the tendency of two or more genes located close together on the same chromosome to be inherited together during cell division. Due to their physical proximity, these genes are considered genetically linked and are likely to be inherited together.
In genetics, the term may also refer to the estimated probability of interaction between multiple loci or specific regions within a target gene. This probability is assessed using data derived from nuclear profiles (NPs), which are thin slices taken from a cell nucleus. Within each NP, the presence or absence of particular loci is evaluated.
These interaction probabilities—referred to as cosegregation values—are used in mathematical models such as SLICE and normalized linkage disequilibrium. These models contribute to the generation of 3D genome architecture maps as part of genome architecture mapping (GAM) techniques. The resulting 3D renderings provide insights into genomic density and the radial positioning of loci within the nucleus.
History
Some of the earliest known studies that have used cosegregation in genealogy dates back to the early 1980s. Around this time, scientists were conducting experiments on vegetative organisms to see if there are unique sequences of chloroplast DNA. The process of the experiment was to track the chloroplast gene in each generation by clustering the genes in nucleoids to reduce the number of segregated units.
Begin with the source’s own compact description: “Cosegregation” is the transmission, together, of 2 or more genes on the same chromosome, as a result of their being in very close physical proximity to one another (i.e., linked). The dossier treats that line as a proposition to test through Cosegregation, transmission and together, not as a finished interpretation.
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Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Jun 2, 2026. The linked authority identifier is Q111953939. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Cosegregation” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.