Chymotrypsin-C
protein-coding gene in the species Homo sapiens
Chymotrypsin-C, also known as caldecrin or elastase 4, is an enzyme that in humans is encoded by the CTRC gene. This enzyme is primarily produced in the pancreas by acinar cells, where it is involved in regulating the activation of digestive enzymes like trypsins and carboxypeptidases.
Function
Chymotrypsin C is a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. In other words, it is involved in breaking peptide bonds in proteins. It catalyzes the preferential cleavage of peptide bonds from the following amino acids:
Leu┼, Tyr┼, Phe┼, Met┼, Trp┼, Gln┼, Asn┼
This is enzyme activity is similar to chymotrypsin A/B (EC 3.4.21.1), but with some differences such as a preference for breaking leucine over phenylalanine bonds.
The public source identifies “Chymotrypsin-C” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around Chymotrypsin-C, protein-coding and gene.
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Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Sep 21, 2026. The linked authority identifier is Q18036476. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Chymotrypsin-C” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.