NAXD
protein-coding gene in the species Homo sapiens
NAD(P)HX dehydratase is an enzyme that in humans is encoded by the NAXD gene (previously CARKD). The NAXD protein is a ATP-dependent NAD(P)H-hydrate dehydratase enzyme that is involved in repairing NAD(P)HX, a type of damaged NAD(P)H.
Gene
Human CARKD gene has 10 exons and resides on Chromosome 13 at q34. The following genes are near CARKD on the chromosome:
COL4A2: A2 Subunit of type IV collagen
RAB20: Potential regulator of Connexin 43 trafficking.
CARS2: Mitochondrial Cystienyl-tRNA Synthetase 2
ING1: Tumor-Suppressor Protein
Tissue distribution
CARKD appears to be ubiquitously expressed at high levels. Expression data in the human protein, and the mouse ortholog, indicate its expression in almost all tissues. One peculiar expression pattern of CARKD is its differential expression through the development of oligodendrocytes. Its expression is lower in oligodendrocyte progenitor cells than in mature oligodendrocytes.
Structure
This protein is part of the phosphomethylpyrimidine kinase: ribokinase / pfkB superfamily. This family is characterized by the presence of a domain shared by the family. CARKD contains a carbohydrate kinase domain (Pfam PF01256).
The public source identifies “NAXD” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around NAXD, protein-coding and gene.
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Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Sep 13, 2026. The linked authority identifier is Q18042010. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “NAXD” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.