Neutropenic enterocolitis
necrotizing inflammation of the cecum
Neutropenic enterocolitis, also known as typhlitis, is an inflammation of the cecum (part of the large intestine) that may be associated with infection. It is particularly associated with neutropenia, a low level of neutrophil granulocytes (the most common form of white blood cells) in the blood.
Typhlitis is a kind of neutropenic enterocolitis. Typhlitis is neutropenic enterocolitis of the ileocecal region, but neutropenic enterocolitis can include other parts of the small intestine and large intestine.
Signs and symptoms
Signs and symptoms of typhlitis may include diarrhea, a distended abdomen, fever, chills, nausea, vomiting, and abdominal pain or tenderness.
Cause
The condition is usually caused by Gram-positive enteric commensal bacteria of the gut (gut flora). Clostridioides difficile is a species of Gram-positive bacteria that commonly causes severe diarrhea and other intestinal diseases when competing bacteria are wiped out by antibiotics, causing pseudomembranous colitis, whereas Clostridium septicum is responsible for most cases of neutropenic enterocolitis.
Typhlitis most commonly occurs in immunocompromised patients, such as those undergoing chemotherapy, patients with AIDS, kidney transplant patients, or the elderly.
Diagnosis
Typhlitis is diagnosed with a radiograph CT scan showing thickening of the cecum and "fat stranding".
Treatment
Typhlitis is a medical emergency and requires prompt management.
“Neutropenic enterocolitis” enters the record as necrotizing inflammation of the cecum. Crown Archives preserves that source wording while asking what Neutropenic, enterocolitis and necrotizing can confirm, complicate or overturn.
Why this record matters
“Neutropenic enterocolitis” is worth following because a concise public description often conceals a longer documentary argument. Here, Neutropenic, enterocolitis and necrotizing provides the most credible route into that argument.
Vocabulary and entity names are the principal evidence signals here, because they determine the precision of every later search. The source revision retrieved here is dated Feb 19, 2025. The linked authority identifier is Q462339. None of the 0 selected statements returned an explicit reference.
A concise general-reference account can conceal disagreements about scope, terminology or the weight assigned to individual sources. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Use the entry as an orientation point, then follow its citations and revision history. Names, dates and institutional relationships should be checked against the original record.
- Subject orientation
- Search vocabulary
- Locating named sources
The closest primary source, responsible institution and strongest cited specialist reference.
Three-step research path
- Establish the record: confirm the title “Neutropenic enterocolitis”, its source revision and the description used here.
- Expand the search: follow Neutropenic enterocolitis primary sources, Neutropenic enterocolitis archive and Neutropenic research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “Neutropenic enterocolitis”?
- Which cited source is closest to the event, object or claim?
- Which institution is responsible for the underlying evidence?
Search terms from this dossier
This entry incorporates text from “Neutropenic enterocolitis” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.