COPP (chemotherapy)
chemotherapy regimen for treatment of non-Hodgkin lymphoma
COPP is a chemotherapy regimen for treatment of Hodgkin lymphoma, consisting of concurrent treatment with Cyclophosphamide, Oncovin, Procarbazine and Prednisone.
Compared with the similar MOPP regimen for both pediatric and adult cases, COPP uses less procarbazine (it is given only for 10 days in cycle instead of 14), and it replaces the very toxic mechlorethamine with cyclophosphamide, which is safer for progenitor stem cells (and hence less prone to causing severe neutropenia) and carries a lower risk of secondary malignancies.
Thus the COPP regimen is considered safer and less toxic than MOPP. But the benefits are offset by its lower efficacy, especially in advanced-stage Hodgkin lymphoma.
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This entry incorporates text from “COPP (chemotherapy)” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.