CMTM2
protein-coding gene in the species Homo sapiens
CKLF-like MARVEL transmembrane domain-containing protein 2 (i.e. CMTM2), previously termed chemokine-like factor superfamily 2 ( i.e. CKLFSF2), is a member of the CKLF-like MARVEL transmembrane domain-containing family (CMTM) of proteins. In humans, it is encoded by the CMTM2 gene located in band 22 on the long (i.e. "q") arm of chromosome 16. CMTM2 protein is expressed in the bone marrow and various circulating blood cells. It is also highly expressed in testicular tissues: The CMTM2 gene and CMTM2 protein, it is suggested, may play an important role in testicular development.
Studies find that the levels of CMTM2 protein in hepatocellular carcinoma tissues of patients are lower than their levels in normal liver tissues. CMTM2 protein levels were also lower in the hepatocellular carcinoma tissues that had a more aggressive pathology and therefore a possible poorer prognosis. Finally, the forced overexpression of CMTM2 protein in cultured hepatocellular tumor cells inhibited their invasiveness and migration.
The public source identifies “CMTM2” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around CMTM2, protein-coding and gene.
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A short description can identify a subject without explaining its stakes. For “CMTM2”, the useful work is to connect “protein-coding gene in the species Homo sapiens” to the records capable of establishing context and consequence.
Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Apr 20, 2026. The linked authority identifier is Q18051443. None of the 0 selected statements returned an explicit reference.
Current terminology should not be projected backward without checking the classification used when the underlying evidence was created. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
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This entry incorporates text from “CMTM2” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.