CLPTM1L
protein-coding gene in the species Homo sapiens
Cleft lip and palate transmembrane protein 1-like protein (CLPTM1-like protein), also known as cisplatin resistance-related protein 9 (CRR9p), is a protein that in humans is encoded by the CLPTM1L gene. CRR9p is associated with cisplatin-induced apoptosis. CLPTM1L, which lies within a cancer susceptibility locus on chromosome 5 (5p15.33), has been found to be commonly over-expressed in lung tumors and to confer resistance to apoptosis caused by genotoxic agents in association with up-regulation of the anti-apoptotic protein, Bcl-xL. Inhibition of CLPTM1L has been shown to inhibit oncogenic transformation and tumorigenesis caused by the KRas oncogene partially through the PI3K/Akt survival signaling axis.
See also
Cleft lip and palate transmembrane protein 1
References
External links
Human CLPTM1L genome location and CLPTM1L gene details page in the UCSC Genome Browser.
The public source identifies “CLPTM1L” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around CLPTM1L, protein-coding and gene.
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This entry incorporates text from “CLPTM1L” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.