CLINT1
protein-coding gene in the species Homo sapiens
Clathrin interactor 1 (CLINT1), also known as EPSIN4, is a protein which in humans is encoded by the CLINT1 gene.
Function
The CLINT1 protein binds to the terminal domain of the clathrin heavy chain and stimulates clathrin cage vesicle assembly. Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal membranes and across the membranes of other types of cells. This enables a turnover of neuroreceptors or other proteins to be maintained and thus the numbers of receptors can be fine tuned.
Clinical significance
The CLINT1 gene has been shown to be involved in the genetic aetiology of schizophrenia in four studies It is known that the antipsychotic drugs chlorpromazine and clozapine stabilise clathrin coated vesicles and this may be one reason why antipsychotic drugs are effective in treating delusions, auditory hallucinations and many of the other symptoms of schizophrenia.
Interactions
CLINT1 has been shown to interact with GGA2.
References
External links
Human CLINT1 genome location and CLINT1 gene details page in the UCSC Genome Browser.
“CLINT1” enters the record as protein-coding gene in the species Homo sapiens. Crown Archives preserves that source wording while asking what CLINT1, protein-coding and gene can confirm, complicate or overturn.
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The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Nov 17, 2025. The linked authority identifier is Q18034581. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “CLINT1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.