CHODL
protein-coding gene in the species Homo sapiens
Chondrolectin is a protein that in humans is encoded by the CHODL gene. Mouse chondrolectin is encoded by Chodl.
Structure
Chondrolectin is a type I membrane protein with a carbohydrate recognition domain characteristic of C-type lectins in its extracellular portion. In other proteins, this domain is involved in endocytosis of glycoproteins and exogenous sugar-bearing pathogens. This protein has been shown to localise to the perinucleus.
Function
The exact function of chondrolectin is unknown but it has been shown to be a marker of fast motor neurons in mice, and is involved in motor neuron development and growth in zebrafish (Danio rerio). Furthermore, human chondrolectin has been shown to localise to motor neurons within the spinal cord.
Clinical significance
Chondrolectin is alternatively spliced in the spinal cord of mouse models of the neuromuscular disease, spinal muscular atrophy (SMA), which predominantly affects lower motor neurons. Increased levels of chondrolectin in a zebrafish model of SMA results in significant improvements in disease-related motor neuron defects.
References
External links
Human CHODL genome location and CHODL gene details page in the UCSC Genome Browser.
Begin with the source’s own compact description: “CHODL” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through CHODL, protein-coding and gene, not as a finished interpretation.
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Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Sep 14, 2026. The linked authority identifier is Q18050827. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “CHODL” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.