CHD1L
protein-coding gene in the species Homo sapiens
Chromodomain-helicase-DNA-binding protein 1-like (ALC1) is an enzyme that in humans is encoded by the CHD1L gene. It has been implicated in chromatin remodeling and DNA relaxation process required for DNA replication, repair and transcription. The ALC1 comprises ATPase domain and macro domain. On the basis of homology within the ATPase domain, ALC1 belongs to Snf2 family.
It has 897 amino acids and is approximately 101kDa in size.
Function
In development
CHD1L, a DNA helicase, possesses chromatin remodeling activity and interacts with PARP1/PARylation in regulating pluripotency during developmental reprogramming. The CHD1L macro-domain interacts with the PAR moiety of PARylated-PARP1 to facilitate early-stage reprogramming and pluripotency in stem cells. It appears that CHD1L expression is vital for early events in embryonic development. CHD1L's role in embryonic development is related to its role as a transcriptional activator of several genes (Akt, METP2, TCF4) which lead to EMT (epithelial to mesenchymal transition) Notably, EMT is also implicated in tumor metastasis, further complicating CHD1L's role in both healthy and diseased cells.
In DNA repair
To allow the critical cellular process of DNA repair, the chromatin must be remodeled at sites of damage.
Begin with the source’s own compact description: “CHD1L” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through CHD1L, protein-coding and gene, not as a finished interpretation.
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This entry incorporates text from “CHD1L” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.