Cyclin-dependent kinase 11B
protein-coding gene in the species Homo sapiens
Cyclin-dependent kinase 11B is an enzyme that in humans is encoded by the CDK11B gene (previously CDC2L1).
This gene encodes a member of the p34Cdc2 protein kinase family. p34Cdc2 kinase family members are known to be essential for eukaryotic cell cycle control. This gene is in close proximity to CDK11A, a nearly identical gene in the same chromosomal region. The gene loci including this gene, CDK11A, as well as metalloprotease MMP21/22, consist of two identical, tandemly linked genomic regions which are thought to be a part of the larger region that has been duplicated. This gene and CDK11A were shown to be deleted or altered frequently in neuroblastoma with amplified MYCN genes. The protein kinase encoded by this gene could be cleaved by caspases and was demonstrated to play roles in cell apoptosis. Several alternatively spliced variants of this gene have been reported.
Interactions
CDK11B has been shown to interact with Cyclin D3.
References
Further reading
External links
Human CDK11B genome location and CDK11B gene details page in the UCSC Genome Browser.
The public source identifies “Cyclin-dependent kinase 11B” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around Cyclin-dependent, kinase and protein-coding.
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