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CGS-21680

chemical compound

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Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionFeb 10, 2024
Entity authorityQ5010992 ↗
Source-derived summary

CGS-21680 is a specific adenosine A2A subtype receptor agonist. It is usually presented as an organic hydrochloride salt with a molecular weight of 536.0 g/M. It is soluble up to 3.4 mg/mL in DMSO and 20 mg/mL in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin.

The chemical is currently used by researchers interested in studying neuronal transmission with a high-affinity, subtype specific analogue for adenosine. This includes research in respiration where it is believed that A2A receptors are involved in rhythm generation in the pre-Bötzinger complex. The drug is not currently approved for use in a therapeutic capacity.

See also

Adenosine receptor

References

Mayer CA, Haxhiu MA, Martin RJ, Wilson CG (2006). "Adenosine A2A receptors mediate GABAergic inhibition of respiration in immature rats". J Appl Physiol. 100 (1): 91–97. doi:10.1152/japplphysiol.00459.2005.

Editorial summary

“CGS-21680” enters the record as chemical compound. Crown Archives preserves that source wording while asking what CGS-21680, chemical and compound can confirm, complicate or overturn.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current lead gives the account dated anchors—2006, 1152, 2005—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around CGS-21680, chemical and compound.
Editorial analysis

Why this record matters

“CGS-21680” is worth following because a concise public description often conceals a longer documentary argument. Here, CGS-21680, chemical and compound provides the most credible route into that argument.

Evidence profile

The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Feb 10, 2024. The linked authority identifier is Q5010992. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2006, 1152 and 2005.

Critical limits

Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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Source & attribution

This entry incorporates text from “CGS-21680” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.