Blaise ketone synthesis
specific chemical reaction
The Blaise ketone synthesis (named after Edmond Blaise) is the chemical reaction of acid chlorides with organozinc compounds to give ketones.[1][2]
The reaction was claimed to bring excellent yields by Blaise, however, investigators failed to obtain better than moderate yields (50%).[3][4] Thus, the reaction is particularly ineffective in forming ketones from acyl chlorides. The reaction also works with organocuprates.[5][6] Reviews have been written.[7][8]
Reaction mechanism
The mechanism is sampled from the proposed mechanism for organocadmium compounds, given that the mechanisms are identical to one another the proposed mechanism for the reaction is the same as the one for organocadmium compounds[9][10].
After the oxygen forms a bond with the organozinc compound, R’ shifts to the carbonyl carbon, having chlorine act as a leaving group and removing the negative charge from zinc. The chlorine that left returns to form a bond with zinc, pushing the electrons back on to oxygen and thus forming the ketone.[11]
Variations
Blaise-Maire reaction
The Blaise-Maire reaction is the Blaise ketone synthesis using β-hydroxy acid chlorides to give β-hydroxyketones, which are converted into α,β-unsaturated ketones using sulfuric acid.[12]
Ketone formation from organocadmium compounds
This ketone formation is an identical reaction to the Blaise ketone synthesis. Only instead of organozinc compounds, organocadmium compounds are used and produce higher yields.
See also
Blaise reaction
Negishi coupling
References
^ Blaise, E. E.; Koehler, A. (1910). "Synthèse au moyen des dérivés organo-métalliques mixtes du zinc (II)". Bull. Soc. Chim.
This brief starts where responsible research should: with the source description of “Blaise ketone synthesis” as specific chemical reaction. Everything that follows is an evidence route, not borrowed authority.
Why this record matters
The subject matters to the science & nature register because the source frames it as specific chemical reaction. Its deeper value depends on whether names, dates, institutions and citations support that framing.
Stable identifiers, scientific names and standards terminology offer the best bridge between this overview and specialist evidence. The source revision retrieved here is dated Jul 8, 2026. The linked authority identifier is Q1058038. None of the 0 selected statements returned an explicit reference. The first chronological checks are 1910.
A general summary may omit uncertainty, sample limits or methodological disagreement that is explicit in the technical record. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
How to read it
Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.
- Current terminology
- Classification context
- Finding cited technical literature
Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.
Three-step research path
- Establish the record: confirm the title “Blaise ketone synthesis”, its source revision and the description used here.
- Expand the search: follow Blaise ketone synthesis primary sources, Blaise ketone synthesis archive and Blaise research across catalogues and specialist indexes.
- Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.
Questions for further research
- Which source most directly establishes the central claim about “Blaise ketone synthesis”?
- Is the terminology current, historical or disputed?
- Which observation, specimen, dataset or publication supports the account?
Search terms from this dossier
This entry incorporates text from “Blaise ketone synthesis” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.