Β-Mannosidase
protein-coding gene in the species Homo sapiens
β-Mannosidase (EC 3.2.1.25}, mannanase, mannase, β-D-mannosidase, β-mannoside mannohydrolase, exo-β-D-mannanase, lysosomal β A mannosidase) is an enzyme with systematic name β-D-mannoside mannohydrolase, which is in humans encoded by the MANBA gene. This enzyme catalyses the following chemical reaction
Hydrolysis of terminal, non-reducing β-D-mannose residues in β-D-mannosides
This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with β-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement.
References
Further reading
External links
Human MANBA genome location and MANBA gene details page in the UCSC Genome Browser.
The public source identifies “Β-Mannosidase” as protein-coding gene in the species Homo sapiens. This brief keeps that definition visible, then builds a research path around Β-Mannosidase, protein-coding and gene.
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