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Integrin beta 3

mammalian protein found in Homo sapiens

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General referenceInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 19, 2025
Entity authorityQ4201964 ↗
Source-derived summary

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes.

Structure and function

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.

Role in endometriosis

Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.

Interactions

CD61 has been shown to interact with PTK2, ITGB3BP, TLN1 and CIB1.

See also

Glycoprotein IIb/IIIa

References

Further reading

External links

CD61+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

ITGB3 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine

Human ITGB3 genome location and ITGB3 gene details page in the UCSC Genome Browser.

Editorial summary

“Integrin beta 3” enters the record as mammalian protein found in Homo sapiens. Crown Archives preserves that source wording while asking what Integrin, beta and mammalian can confirm, complicate or overturn.

Editorial reviewA practical starting point whose main value is the path it opens into stronger specialist and primary sources. The current lead gives the account dated anchors—2014—that can be checked directly. The selected authority fields contribute no independent date. Its strongest next move is a source search built around Integrin, beta and mammalian.
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“Integrin beta 3” is worth following because a concise public description often conceals a longer documentary argument. Here, Integrin, beta and mammalian provides the most credible route into that argument.

Evidence profile

Named sources, stable identifiers and responsible institutions provide the strongest route from overview to verifiable evidence. The source revision retrieved here is dated Jul 19, 2025. The linked authority identifier is Q4201964. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2014.

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Source & attribution

This entry incorporates text from “Integrin beta 3” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.