BLCAP
protein-coding gene in the species Homo sapiens
Bladder cancer-associated protein is a protein that in humans is encoded by the BLCAP gene.
Function
BLCAP was identified using a differential display procedure with tumor biopsies obtained from a noninvasive and an invasive bladder transitional cell carcinoma. Although database searches revealed no homology to any human gene at the time of identification, mouse, rat and zebrafish orthologs have since been identified. The protein appears to be down-regulated during bladder cancer progression.
The protein also known as BC10 is an 87-amino-acid-long protein, but its biological functions are largely unknown. However it is a widely believed that the protein is involved in tumour suppression by decreasing cell growth through initiating apoptosis. It is widely expressed protein but expression is particularly high in brain and B lymphocytes. Alternative promoters and alternative splicing allow the protein to exist as several different transcript variants. This number is further increased as the pre-mRNA of this protein is subject to several RNA editing events.
Structure
The structure of the protein is predicted to be a globular protein with 2 transmembrane (TM) domains.
This brief starts where responsible research should: with the source description of “BLCAP” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.
Why this record matters
The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Mar 22, 2026. The linked authority identifier is Q18035935. None of the 0 selected statements returned an explicit reference.
A general summary may omit uncertainty, sample limits or methodological disagreement that is explicit in the technical record. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.
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- Current terminology
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Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.
Three-step research path
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Questions for further research
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This entry incorporates text from “BLCAP” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.