CACrown ArchivesThe cinema collection
EN/FR
Search
Menu
Research dossier · Science & Nature

Bradykinin receptor B1

protein-coding gene in the species Homo sapiens

Specimen drawers, botanical folios and brass scientific instruments under study light
Science and natureInterpretive dossier study · Crown Archives visual atlas
Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 16, 2025
Entity authorityQ18016454 ↗
Source-derived summary

Bradykinin receptor B1 (B1) is a G-protein coupled receptor encoded by the BDKRB1 gene in humans. Its principal ligand is bradykinin, a 9 amino acid peptide generated in pathophysiologic conditions such as inflammation, trauma, burns, shock, and allergy. The B1 receptor is one of two of G protein-coupled receptors that have been found which bind bradykinin and mediate responses to these pathophysiologic conditions.

B1 protein is synthesized de novo following tissue injury and receptor binding leads to an increase in the cytosolic calcium ion concentration, ultimately resulting in chronic and acute inflammatory responses.

Classical agonist of this receptor includes bradykinin1-8 (bradykinin with the first 8 amino acid) and antagonist includes [Leu8]-bradykinin1-8.

Antagonists

LF22-0542

See also

Bradykinin receptor

References

External links

"Bradykinin Receptors: B1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-11-25.

Editorial summary

This brief starts where responsible research should: with the source description of “Bradykinin receptor B1” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.

Editorial reviewA practical orientation to terminology and classification, particularly when read beside dated observations, specimens or technical literature. The current lead gives the account dated anchors—2016, 2008—that can be checked directly. The selected authority fields contribute no independent date. The account is most persuasive where Bradykinin, receptor and protein-coding can be independently traced.
Editorial analysis

Why this record matters

The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 16, 2025. The linked authority identifier is Q18016454. None of the 0 selected statements returned an explicit reference. The first chronological checks are 2016 and 2008.

Critical limits

Scientific names, classifications and consensus can change while older terminology persists in catalogues and historical literature. The lead is largely declarative, so disagreement and counter-evidence require a deliberate search beyond the opening account. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

How to read it

Check terminology, classification and the date of the cited evidence. Scientific names and technical consensus can change while older records retain historical value.

Best used for
  • Current terminology
  • Classification context
  • Finding cited technical literature
Verify next

Primary datasets, specimen catalogues, standards bodies and the most recent peer-reviewed literature.

Three-step research path

  1. Establish the record: confirm the title “Bradykinin receptor B1”, its source revision and the description used here.
  2. Expand the search: follow Bradykinin receptor B1 primary sources, Bradykinin receptor B1 archive and Bradykinin research across catalogues and specialist indexes.
  3. Test the account: compare the strongest cited source with the responsible institution’s current record and note any disagreement.

Questions for further research

  1. Which source most directly establishes the central claim about “Bradykinin receptor B1”?
  2. Which observation, specimen, dataset or publication supports the account?
  3. Is the terminology current, historical or disputed?
Subject index

Search terms from this dossier

Source & attribution

This entry incorporates text from “Bradykinin receptor B1” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.