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Research dossier · Science & Nature

Cyclin B2

protein-coding gene in the species Homo sapiens

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Record originEnglish Wikipedia
Text licenseCC BY-SA 4.0
Source revisionJul 16, 2025
Entity authorityQ18033857 ↗
Source-derived summary

G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene.

Function

Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.

Interactions

Cyclin B2 has been shown to interact with TGF beta receptor 2.

Editorial summary

Begin with the source’s own compact description: “Cyclin B2” is protein-coding gene in the species Homo sapiens. The dossier treats that line as a proposition to test through Cyclin, protein-coding and gene, not as a finished interpretation.

Editorial reviewUseful for establishing the present vocabulary of the subject while preserving a route back to the evidence on which that vocabulary rests. The current 110-word lead offers orientation but no explicit four-digit date, so chronology should not be assumed. The selected authority fields contribute no independent date. For this dossier, Cyclin, protein-coding and gene is the immediate research focus.
Editorial analysis

Why this record matters

The phrase “protein-coding gene in the species Homo sapiens” supplies a clear boundary for inquiry. It also exposes the unanswered questions: who defined that boundary, when it became stable and which sources sit outside it.

Evidence profile

Datasets, specimens, observations and peer-reviewed methods provide the appropriate test for the technical claims summarized here. The source revision retrieved here is dated Jul 16, 2025. The linked authority identifier is Q18033857. None of the 0 selected statements returned an explicit reference.

Critical limits

A general summary may omit uncertainty, sample limits or methodological disagreement that is explicit in the technical record. The source lead contains qualifying language; that uncertainty should survive quotation, summary and reuse. Authority statements aid reconciliation but still require their own references, qualifiers and ranks to be checked.

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Source & attribution

This entry incorporates text from “Cyclin B2” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.