Asparagine synthase (glutamine-hydrolysing)
class of enzymes
Asparagine synthase (glutamine-hydrolysing) (EC 6.3.5.4, asparagine synthetase (glutamine-hydrolysing), glutamine-dependent asparagine synthetase, asparagine synthetase B, AS, AS-B) is an enzyme with systematic name L-aspartate:L-glutamine amido-ligase (AMP-forming). This enzyme catalyses the following chemical reaction
ATP + L-aspartate + L-glutamine + H2O
⇌
{\displaystyle \rightleftharpoons }
AMP + diphosphate + L-asparagine + L-glutamate (overall reaction)
(1a) L-glutamine + H2O
⇌
{\displaystyle \rightleftharpoons }
L-glutamate + NH3
(1b) ATP + L-aspartate + NH3
⇌
{\displaystyle \rightleftharpoons }
AMP + diphosphate + L-asparagine
The enzyme from Escherichia coli has two active sites.
“Asparagine synthase (glutamine-hydrolysing)” enters the record as class of enzymes. Crown Archives preserves that source wording while asking what Asparagine, synthase and glutamine-hydrolysing can confirm, complicate or overturn.
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This entry incorporates text from “Asparagine synthase (glutamine-hydrolysing)” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.