Lofepramine
chemical compound
Lofepramine, sold under the brand names Gamanil, Lomont, and Tymelyt among others, is a tricyclic antidepressant (TCA) which is used to treat depression. The TCAs are so named as they share the common property of having three rings in their chemical structure. Like most TCAs lofepramine is believed to work in relieving depression by increasing concentrations of the neurotransmitters norepinephrine and serotonin in the synapse, by inhibiting their reuptake. It is usually considered a third-generation TCA, as unlike the first- and second-generation TCAs it is relatively safe in overdose and has milder and less frequent side effects.
Lofepramine is not available in the United States, Canada, Australia or New Zealand, although it is available in Ireland, Japan, South Africa and the United Kingdom, among other countries.
Depression
In the United Kingdom, lofepramine is licensed for the treatment of depression which is its primary use in medicine.
Lofepramine is an efficacious antidepressant with about 64% patients responding to it.
Contraindications
To be used with caution, or not at all, for people with the following conditions:
Heart disease
Impaired kidney or liver function
Narrow angle glaucoma
In the immediate recovery period after myocardial infarction
In arrhythmias (particularly heart block)
Mania
In severe liver and/or severe renal impairment
And in those being treated with amiodarone or terfenadine.
Pregnancy and lactation
Lofepramine use during pregnancy is advised against unless the benefits clearly outweigh the risks. This is because its safety during pregnancy has not been established and animal studies have shown some potential for harm if used during pregnancy.
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