Amphiphysin
protein-coding gene in the species Homo sapiens
Amphiphysin is a protein that in humans is encoded by the AMPH gene.
Function
This gene encodes a protein associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff person syndrome who were also affected by breast cancer are positive for autoantibodies against this protein. Alternate splicing of this gene results in two transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.
Interactions
Amphiphysin has been shown to interact with DNM1, Phospholipase D1, CDK5R1, PLD2, CABIN1 and SH3GL2.
See also
Ap180 – ProteinPages displaying short descriptions with no spaces
Epsin
References
Further reading
External links
Bringing your curves to the bar, amphiphysin home page
Human AMPH genome location and AMPH gene details page in the UCSC Genome Browser.
This brief starts where responsible research should: with the source description of “Amphiphysin” as protein-coding gene in the species Homo sapiens. Everything that follows is an evidence route, not borrowed authority.
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The subject matters to the science & nature register because the source frames it as protein-coding gene in the species Homo sapiens. Its deeper value depends on whether names, dates, institutions and citations support that framing.
The date and method of observation matter as much as the stated conclusion, especially where classification or consensus has changed. The source revision retrieved here is dated Jul 15, 2026. The linked authority identifier is Q14906081. None of the 0 selected statements returned an explicit reference.
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This entry incorporates text from “Amphiphysin” on English Wikipedia. Contributors are listed in the page history. Text is available under the Creative Commons Attribution-ShareAlike 4.0 License. Selected authority identifiers and statements are retrieved from Wikidata under CC0; their references and qualifiers remain part of the verification path.